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Friday, August 7, 2020 | History

2 edition of Sialic acid and the function of HGG and LH. found in the catalog.

Sialic acid and the function of HGG and LH.

Eylard Vicente van Hall

Sialic acid and the function of HGG and LH.

by Eylard Vicente van Hall

  • 57 Want to read
  • 4 Currently reading

Published in [Nijmegen] .
Written in English

    Subjects:
  • Sialic acids -- Physiological effect.,
  • Chorionic gonadotropins -- Metabolism.,
  • Luteinizing hormone -- Metabolism.

  • Classifications
    LC ClassificationsQP801.S47 H34
    The Physical Object
    Pagination46 p.
    Number of Pages46
    ID Numbers
    Open LibraryOL4491250M
    LC Control Number79321003

    Thus, their sialic acid profiles during metamorphosis were different from the tail's profile. These data show that sialic acid may be an indicator of the presence of some cellular events during metamorphosis and that it can have different roles in the developmental process   Sialic acid shields human cells from attack by immune system Date: Novem Source: Universitaet Tübingen Summary: Biochemists have identified molecular structures that

    sialic acid residue in the binding pocket with one side of the pyranose ring in tight contact to the protein and the other side facing the solvent (Fig. 1). From this model potential hydrogen bonds and van der Waals contacts of sialic acid atoms with amino acids in the binding pocket are predicted [ A,-   Sialic acids are critical in determining glycoprotein bioavailability, function, stability, and metabolism.1 Although over 50 natural sialic acids have been identified,2 ™ two forms are commonly determined in glycoprotein products: N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc). Because

    Sialic acid is the terminal sugar found on most glycoproteins and is crucial in determining serum half-life and immunogenicity of acid analogs are antiviral therapeutics as well as crucial tools in bacterial pathogenesis research, immunobiology and development of cancer diagnostic imaging. The scarce supply of sialic acid hinders production of these :// 1H-NMR Spectroscopy.- 1. N-Acetyl- and N-Glycolylneuraminic Acid.- 2. O-Acetylated Neuraminic Acid Derivatives.- 3. Analysis of Sialic Acid Linkage Types in Glycoconjugates.- a) The Anomeric Configuration of Sialic Acid.- b) Sialic Acid in Carbohydrate Chains of the N-Acetyllactosamine Type.- c) Sialic Acid in 0-Glycosidically Linked


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Sialic acid and the function of HGG and LH by Eylard Vicente van Hall Download PDF EPUB FB2

Sialic acid and the function of HGG and LH [Eylard Vicente van Hall] on *FREE* shipping on qualifying :// Buy Sialic acid and the function of HGG and LH by Eylard Vicente van Hall (ISBN:) from Amazon's Book Store.

Everyday low prices and free delivery on eligible :// Title: Sialic acid and the function of HCG and LH: Author(s): Hall, E.V. van: Publication year: Publisher: Sialic acids (Sias) comprise a family of 9-carbon carboxylated sugars.

The Sia family consists of nearly 50 members that are derivatives of N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic acid (Neu5Gc), and 3-deoxy-d-glycero-d-galacto-nonulopyranosonic acid (deaminoneuraminic acid; 2-ketodeoxy-d-glycero-d-galacto-nononic acid; Kdn) (Fig.

1 The diversity of these structures is /biochemistry-genetics-and-molecular-biology/sialic-acid. Most sialic acids are derivatives of neuraminic acid, e.g. N -acetylneuraminic acid (Neu5Ac) or N -acetyl O -acetylneuraminic acid (Neu5,9Ac 2).

Desaminoneuraminic acid is 2-keto desoxy   Free sialic acid is found in urine, particularly in patients with the disease sialuria, where up to 7 g of sialic acid can be eliminated in 1 day (Montreuil et al, ). Sialic acid is a 1.

Author(s): Hall,Eylard Vicente van Title(s): Sialic acid and the function of HCG and LH/ door Eylard Vicente van Hall. Country of Publication: Netherlands Publisher: [Nijmegen: s.n.], As knowledge is increasing about the involvement of sialic acids in many aspects of cell biology, another chapter is devoted to these phenomena.

With this book I intend to demonstrate modern trends in sialic acid chemistry and biochemistry, and I hope that it will be of practical use and find its place in laboratories rather than in  › Life Sciences › Biochemistry & Biophysics.

Sialic acids represent a family of sugar molecules with an unusual and highly variable chemical structure that are found mostly in the terminal position of oligosaccharide chains on the surface of cells and molecules. These special features enable them to fulfil several important and even diametrical biological functions.

Because of the great importance of sialic acids, it is also worth having   Sialic acid synthesis in animals takes place primarily in the cytosol and involves four enzymes participating in a five-step process (see Figure 3).The dual activity enzyme UDP-GlcNAc 2-epimerase/ ManNAckinase (gene symbol GNE) converts the starting substrate uridine 5'-diphosphate-N-acetyl-D-glucosamine (UDPGlcNAc) to N-acetyl-D-mannosamine (ManNAc) with removal of the /biofiles/biofiles/   Structures of the most abundant members of the sialic acid family.

These sialic acids exist in α2,3- and in α2,6-linkage to galactose-containing glycans or in α2,6-linkage to N-acetylgalactosamine residues (Figure 3). They can also be linked via an α2,8-linkage to other sialic acid moieties (polysialic acid article HMIO and This concise volume examines the historical development of the field and reviews current knowledge on the genetic, immunologic, oncologic, neurodevelopmental, pathogenic, and cell regulatory properties of sialic acid.

Outstanding features of this work include exhaustive reference material and detailed information ://   1) Qualitative Standards: Sialic Acid reference Panel (SRP) and Neu5,9Ac 2 The sialic acid reference panel (SRP) contains Neu5Gc, Neu5Ac, Neu5,7Ac 2, Neu5Gc9Ac, Neu5,9Ac 2, and Neu5,7,(8),9Ac 3.

SRP is used as a system suitability standard. The DMB profile for the sialic acid reference panel is shown in Figure 3A. The Neu5,9Ac 2   Loss of sialic acid can affect equine LH in contrasting ways; increasing in vitro biological activity, but reducing in vivo half-life.

Bioactive FSH in serum was reported to increase, indicating a shift towards the basic forms, during pregnancy in humans (i.e. when steroid concentrations are physiologically high) while immunoactive FSH A new, sialic-acid-derived compound was isolated from the acid hydrolysate of edible bird's nest by ion-exchange chromatography.

Combined use of mass spectroscopy and 1H- and 13C-NMR spectroscopy /_Isolation_and_Purification_of_Sialic_Acids. Sialic acids occur widely as glycoconjugates at the nonreducing ends of glycans.

Glycosphingolipids (GSLs) include a large number of sialyl-linked glycan isomers with α2,3- α2,6- and α2,8-linked polysialic acids. Thus, it is difficult to distinguish structural isomers with the same mass by mass spectrometry. The sialic acid linkage specific alkylamidation (SALSA) method has been   the exception with respect to the function of sialic acid, and that sialic acid plays a previously unrecognized role in regulating survival in the circulation of the large majority of glycoproteins tested.

MATERIALS AND METHODS Clostridium perfringens neuraminidase ( units per mg), Enzymatic Glycosidations of Sialic Acids Sialyltransferases Metabolic Engineering of the Sialic Acid Biosynthetic Pathway.

Sialidases. Synthesis of C‐ and S‐Glycosides of Sialic Acid Introduction. Sialic acids are a family of α-keto acids with a nine-carbon backbone.

More than 50 sialic acid forms have been found in nature including the most abundant N-acetylneuraminic acid (Neu5Ac), non-human N-glycolylneuraminic acid (Neu5Gc), 2-ketodeoxy-nonulosonic acid (or deaminoneuraminic acid) (Kdn), and their O-methyl, O-lactyl, O-sulfo, O-phospho- single or multiple Get this from a library.

Sialic Acids: Chemistry, Metabolism, and Function. [Roland Schauer] -- Rapid progress in the field of sialic acids has made it desirable to collect the new data about these unique sugars and to continue the series of books on this topic.

InA. GOTTSCHALK wrote. Total sialic acid was estimated by modifying the procedure of Svennerholm (47). The sample ( ml) was treated with ml of the resorcinol reagent, heated at ” for 15 min in covered test tubes, chilled in ice, mixed with 2 ml of 1-butanol.

The butanol intensified and stabilized color; absorbances were Although over 50 natural sialic acids have been identified, two forms are commonly determined in therapeutic glycoprotein products: N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid Sialic acids (neuraminic acids) are a diverse family of nine carbon (nonulosonic) α-keto acidic carbohydrates.

The canonical sialic acid, 2-ketodeoxyacetamido-D-glycero-D-galacto-nonulosonic acid, also known as N-acetylneuraminic acid (Neu5Ac) is the backbone on which a large number of known modifications are made (1). The Neu5Ac structure is typified by a 6-carbon carboxylic acid